Executive Summary
Next-generation OX2R agonist with differentiated profile for neurological and neurodegenerative disorders
ORX142
OX2R · OX2R agonist
Mechanism of Action
TypeSelective OX2R agonist (small molecule)
DescriptionHighly potent and selective OX2R agonist with a pharmacological profile differentiated from ORX750, optimized for neurological indications
Indications: Neurological and neurodegenerative disorders
Target Biology
Same OX2R target as ORX750, but ORX142 is designed with a differentiated pharmacological profile optimized for neurological and neurodegenerative conditions where cognitive function, neuroprotection, and sustained wakefulness may be key therapeutic goals.
Clinical Data
No clinical trial data available.
Market Opportunity
Catalysts & Upcoming Events
| Event | Timing | Importance | Key Metrics to Watch | Consensus |
|---|---|---|---|---|
| Patient study initiation | Q1 2026 | high | Which neurological indication is selected for patient studies | — |
| Patient study initiation for neurological disorders | Q1 2026 | high | — | — |